List of modelled CCP modules (aka sushi domains, SCRs) with names and accession numbers

Table of experimentally solved CCP modules (23/10/2009) [ PDF ]

Table of residue lengths of CCP module domain boundaries and inter-CCP module linkers in RCA proteins [ PDF ]

Table of intermodular tilt, twist and skew angles for all solved CCP bimodules and larger fragments [ PDF ]

Table of buried surface area for CCP bimodules [ PDF ]

Table of predicted structural effects of factor H disease-associated sequence variants [ PDF ]

The molecular architectures of the set of human CCP-module containing proteins are taken from SMART [Schultz et al., 1998, Letunic et al., 2002] and the CCP modules are numbered according to SMART annotations (NOTE: SMART did not detect the following modules: CR2~08, FHR3~05, FHR4~05 and FHR5~09). In this work, module domain boundaries for each CCP module were considered from one residue before the first cysteine until three residues after the fourth cysteine (both inclusive).

Click directly on the CCP module to open or save the PDB file. All experimentally solved structure modules have an "EXP: " label preceding the module name. If a particular module was not modelled, a label "NO MODEL: " precedes the module name. In these cases, the link provided should take you directly to the SMART annotation for that bit of the protein sequence. Please use the labels provided as a guide, else directly check against the complete tabulated list provided above.

Reference: Dinesh C. Soares, Dietlind L. Gerloff, Neil R. Syme, Andrew F. Coulson, John Parkinson and Paul N. Barlow
Large-scale modelling as a route to multiple surface comparisons of the CCP module family.
Protein Eng Des Sel. 2005 Aug;18(8):379-88. Epub 2005 Jun 23. [Abstract] [PDF]

Human CCP-module containing proteins involved in complement

DAF SIGNAL EXP: DAF~01 EXP: DAF~02 EXP: DAF~03 EXP: DAF~04 MCP EXP: MCP~01 EXP: MCP~02 MODEL: MCP~03 MODEL: MCP~04 TRANS VCP EXP: VCP~01 EXP: VCP~02 EXP: VCP~03 EXP: VCP~04
C4BPα SIGNAL EXP: C4BPa~01 EXP: C4BPa~02 MODEL: C4BPa~03 MODEL: C4BPa~04 MODEL: C4BPa~05 NO MODEL: C4BPa~06 MODEL: C4BPa~07 MODEL: C4BPa~08 C4BPβ SIGNAL NO MODEL: C4BPb~01 MODEL: C4BPb~02 MODEL: C4BPb~03
CR1 SIGNAL MODEL: CR1~01 MODEL: CR1~02 MODEL: CR1~03 MODEL: CR1~04 MODEL: CR1~05 MODEL: CR1~06 MODEL: CR1~07 MODEL: CR1~08 MODEL: CR1~09 MODEL: CR1~10 MODEL: CR1~11 MODEL: CR1~12 MODEL: CR1~13 MODEL: CR1~14 EXP: CR1~15 EXP: CR1~16 EXP: CR1~17 MODEL: CR1~18 MODEL: CR1~19 MODEL: CR1~20 MODEL: CR1~21 MODEL: CR1~22 MODEL: CR1~23 MODEL: CR1~24 MODEL: CR1~25 MODEL: CR1~26 MODEL: CR1~27 MODEL: CR1~28 MODEL: CR1~29 MODEL: CR1~30 TRANS
CR2 SIGNAL EXP: CR2~01 EXP: CR2~02 MODEL: CR2~03 MODEL: CR2~04 MODEL: CR2~05 MODEL: CR2~06 MODEL: CR2~07 MODEL: CR2~09 MODEL: CR2~10 MODEL: CR2~11 MODEL: CR2~12 MODEL: CR2~13 MODEL: CR2~14 MODEL: CR2~15 TRANS
Factor H SIGNAL EXP: FH~01 EXP: FH~02 EXP: FH~03 MODEL: FH~04 EXP: FH~05 EXP: FH~06 EXP: FH~07 EXP: FH~08 NO MODEL: FH~09 NO MODEL: FH~10 MODEL: FH~11 MODEL: FH~12 NO MODEL: FH~13 MODEL: FH~14 EXP: FH~15 EXP: FH~16 MODEL: FH~17 MODEL: FH~18 EXP: FH~19 EXP: FH~20
FHR-1 SIGNAL NO MODEL: FHR1~01 NO MODEL: FHR1~02 MODEL: FHR1~03 MODEL: FHR1~04 NO MODEL: FHR1~05 FHR-2 SIGNAL NO MODEL: FHR2~01 NO MODEL: FHR2~02 MODEL: FHR2~03 NO MODEL: FHR2~04 FHR-3 SIGNAL NO MODEL: FHR3~01 NO MODEL: FHR3~02 NO MODEL: FHR3~03 MODEL: FHR3~04 NO MODEL: FHR3~05
FHR-4 SIGNAL NO MODEL: FHR4~01 NO MODEL: FHR4~02 NO MODEL: FHR4~03 MODEL: FHR4~04 NO MODEL: FHR4~05 FHR-5 SIGNAL NO MODEL: FHR5~01 NO MODEL: FHR5~02 MODEL: FHR5~03 MODEL: FHR5~04 MODEL: FHR5~05 MODEL: FHR5~06 MODEL: FHR5~07 MODEL: FHR5~08
Factor B SIGNAL EXP: FactorB~01 EXP: FactorB~02 EXP: FactorB~03 VWA Tryp_Sc
C2 SIGNAL NO MODEL: C2~01 MODEL: C2~02 MODEL: C2~03 VWA Tryp_SPc
C6 SIGNAL TSP1 TSP1 LDLa MACPF TSP1 NO MODEL: C6~01 MODEL: C6~02 FIMAC FIMAC
C7 SIGNAL TSP1 LDLa MACPF TSP1 MODEL: C7~01 NO MODEL: C7~02 FIMAC FIMAC
C1s CUB EGF_CA CUB NO MODEL: C1s~01 EXP: C1s~02 C1r CUB EGF_CA CUB EXP: C1r~01 EXP: C1r~02 Tryp_SPc
MASP-1 CUB EGF_CA CUB NO MODEL: MASP1~01 MODEL: MASP1~02 Tryp_SPc MASP-2 CUB EGF_CA CUB EXP: MASP2~01 EXP: MASP2~02 Tryp_SPc

Non-complement human CCP module containing proteins




Many thanks to Russell Hamilton for help in automating creation of IMAGE MAPS for this site.
For questions, comments and suggestions- email Dinesh Soares: Dinesh.Soares@ed.ac.uk